Is dobutamine weight-based?
Dosing of dobutamine is weight- based; atropine dose is not adjusted based on weight or body mass index (BMI).
Which drugs are dosed on ideal body weight?
Dosing Weights
| Drug Name | Adjustment in Obesity |
|---|---|
| Daptomycin | Adjusted Body Weight when patient weight >120% of ideal body weight Total Body Weight when <=120% of ideal body weight |
| Ethambutol | Ideal Body Weight when patient weight >120% of ideal body weight |
How does obesity affect drug dosing?
When lean body weight increases there will be a corresponding increase in drug clearance and an increased dose may be required. Commonly used weight-based drugs that may require dose adjustment and monitoring in obesity, and in particular morbid obesity, are listed in Table 2.
What happens when an obese person is given with a lipophilic drug?
With lipophilic drugs (e.g., barbiturates, benzodiazepines), this parameter is significantly increased, explaining the prolongation of the plasma elimination half-life. For drugs that are almost equally soluble in water and oil (methyl xanthines, aminoglycosides), the V is slightly increased in the obese.
How does weight affect drug distribution?
The main factors that affect the tissue distribution of drugs are body composition, regional blood flow and the affinity of the drug for plasma proteins and/or tissue components. Obese people have larger absolute lean body masses as well as fat masses than non-obese individuals of the same age, gender and height.
Is medication dosed by weight?
Medication dosing is often calculated on the basis of a patient’s weight, particularly for pediatric patients, who require individualized dose calculations based on their size.
How does weight affect drug effectiveness?
Changes in body weight can influence the amount of medicine you need to take and how long it stays in your body. The circulatory system may slow down, which can affect how fast drugs get to the liver and kidneys.
Is the standard weight-based dosing of dobutamine for stress testing appropriate?
The current weight-based protocol of dobutamine dosing for DST results in similar increases in HR and blood pressure for patients of widely varying BMI. Is the standard weight-based dosing of dobutamine for stress testing appropriate for patients of widely varying body mass index? J Cardiovasc Pharmacol Ther.
Does dobutamine affect blood pressure and heart rate?
The current weight-based protocol of dobutamine dosing for DST results in similar increases in HR and blood pressure for patients of widely varying BMI. The current weight-based protocol of dobutamine dosing for DST results in similar increases in HR and blood pressure for patients of widely varying BMI.
What is the maximum amount of insulin that can be administered?
-Concentrations up to 5000 mcg/mL have been administered to humans. Determine final volume based on fluid requirements of the patient. -No controlled-trial experience exists beyond 48 hours of repeated boluses and/or continuous infusions.
