What is stereoselectivity in organic chemistry?
Illustrated Glossary of Organic Chemistry – Stereoselective. Stereoselective: A reaction in which only one stereoisomer among a mixture of stereoisomers reacts. Also a reaction that can in principle produce two or more stereoisomers but in fact produces one (or almost only one) stereoisomer product.
What is stereoselectivity and stereospecificity?
A stereospecific mechanism specifies the stereochemical outcome of a given reactant, whereas a stereoselective reaction selects products from those made available by the same, non-specific mechanism acting on a given reactant.
What do you mean by stereoselective synthesis?
Stereoselective synthesis focuses on the selective generation of a stereogenic center in a molecule in either of two configurations. A stereogenic center is created by transformation of a prochiral entity.
What is stereoselectivity in pharmacology?
Stereoselective metabolism of drugs is most commonly the major contributing factor to stereoselectivity in pharmacokinetics. Metabolizing enzymes often display a preference for one enantiomer of a chiral drug over the other, resulting in enantioselectivity.
Why is stereoselectivity important?
Stereoselectivity in drug metabolism can not only influence the pharmacological activities, tolerability, safety, and bioavailability of drugs directly, but also cause different kinds of drug–drug interactions.
What causes stereoselectivity?
A stereoselective process is one in which one stereoisomer predominates over another when two or more may be formed. If the products are enantiomers, the reaction is enantioselective; if they are diastereoisomers, the reaction is diastereoselective.
What do is the principle of stereoselectivity?
In chemistry, stereoselectivity is the property of a chemical reaction in which a single reactant forms an unequal mixture of stereoisomers during a non-stereospecific creation of a new stereocenter or during a non-stereospecific transformation of a pre-existing one.
Why is Stereoselectivity important?
How does stereochemistry affect drug action?
Stereochemistry is of critical importance to drug action because the shape of a drug molecule is an important factor in determining how it interacts with the various biological molecules (enzymes, receptors, etc.) that it encounters in the body.
What are the effects of stereoselectivity?
Factors Affecting Stereoselectivity. Stereoselectivity in radical reactions is determined by a combination of factors that includes steric, stereoelectronic, conformational, torsional, and configurational effects as well as reaction temperature. Each of these effects can be linked to a particular aspect of structure.