What are the metabolites of Valium?
The most common metabolites of Valium are nordiazepam, temazepam, and oxazepam. The metabolites of the drug may have much longer half-lives as well. Nordiazepam, for example, has a half-life of up to 100 hours.
How is Valium metabolised?
Brand names include Valium, Diastat Acudial, Diastat, and Diazepam Intensol. Diazepam is primarily metabolized by CYP3A4 and CYP2C19 to the major active metabolite, desmethyldiazepam.
What does diazepam metabolized into?
Diazepam metabolic pathway. Diazepam is metabolized to either nordiazepam by CYP 2C19 or temazepam by CYP3A4. Nordiazepam and temazepam are hydroxylated and demethylated to oxazepam. Oxazepam is then glucuronidated and excreted in the urine.
What is oxazepam a metabolite of?
Oxazepam is a short-acting benzodiazepine and one of the most frequently prescribed anxiolytic drugs. It is also the active metabolite of a wide range of other benzodiazepines, such as diazepam, ketazolam, temazepam, chlordiazepoxide, demoxazepam, halazepam, medazepam, prazepam, pinazepam, and chlorazepate.
What is metabolized by CYP2C19?
CYP2C19 catalyzes the metabolism of several drugs, including proton pump inhibitors (PPIs) (e.g., omeprazole, lansoprazole, pantoprazole), antidepressants (e.g., citalopram and amitriptyline), antiplatelet drugs (e.g., clopidogrel), antifungals (e.g., voriconazole), and anticancer compounds (e.g., cyclophosphamide).
What are the types of metabolites?
The metabolites can be grouped into two major types: primary and secondary. Primary metabolites are those that are directly involved in the growth, development, and reproduction of an organism whereas secondary metabolites are those that are not.
What is CYP2C19 rapid metabolizer?
In people who are rapid metabolizers, the CYP2C19 enzyme has high activity. People who are rapid metabolizers break down some medicines quickly and may need different doses or a different medicine. About 29% of our patients are rapid metabolizers.
What is the pathophysiology of mercaptopurine metabolism?
Mercaptopurine is metabolized via 2 major pathways. Mercaptopurine is rapidly and extensively oxidized to 6-thiouric acid in the liver by the enzyme xanthine oxidase. Because xanthine oxidase is inhibited by allopurinol, concomitant use of this drug decreases the metabolism of mercaptopurine and its active metabolites and leads to toxicity.
Does mercaptopurine volatilize in soil?
Mercaptopurine is not expected to volatilize from dry soil surfaces (SRC) based upon an estimated vapor pressure of 1.3X10-8 mm Hg (SRC), determined from a fragment constant method (2). Biodegradation data in soil were not available (SRC, 2016).
Is there a drug warnings (complete) for mercaptopurine?
For more Drug Warnings (Complete) data for Mercaptopurine (20 total), please visit the HSDB record page. Mercaptopurine is one of a large series of purine analogues which interfere with nucleic acid biosynthesis and has been found active against human leukemias.
What is the molecular formula of mercaptopurine?
Mercaptopurine PubChem CID 667490 Structure Find Similar Structures Chemical Safety Laboratory Chemical Safety Summary (LCSS Molecular Formula C5H4N4S Synonyms 6-Mercaptopurine mercaptopurine 50-44-2