Is cyclophosphamide a strong chemo drug?
It was discovered that — in addition to its usefulness in cancer — cyclophosphamide also has a significant ability to suppress the immune system. Thus, the medicine is very effective in the treatment of immunologically–mediated diseases, including some forms of vasculitis.
How long can you take cyclophosphamide?
Most patients are NOT on cyclophosphamide indefinitely. Most physicians will discuss with their patients a time line of how long they will require cyclophosphamide (E.g. 3, 6, or 12 months).
When should I take cyclophosphamide?
Usually it is best to take cyclophosphamide first thing in the morning, to reduce the risk of bladder problems. However, your doctor may want you to take it with food in smaller doses over the day, to lessen stomach upset or help the medicine work better.
What are side effects of cyclophosphamide?
Nausea, vomiting, loss of appetite, stomach ache, diarrhea, or darkening of the skin/nails may occur. Nausea and vomiting can be severe. In some cases, drug therapy may be necessary to prevent or relieve nausea and vomiting.
Does cyclophosphamide cause weight loss?
describe an anti-obesity effect of the commonly prescribed drugs methotrexate and cyclophosphamide on obesity in mice. These drugs act as anti-folate and DNA alkylating agents [2, 3], but in spite of their different mechanisms of action, both cause substantial weight loss at sub-lethal doses.
What cancers is cyclophosphamide used for?
Cyclophosphamide is used to treat cancer of the ovaries, breast, blood and lymph system, and nerves (mainly in children). Cyclophosphamide is also used for retinoblastoma (a type of eye cancer mainly in children), multiple myeloma (cancer in the bone marrow), and mycosis fungoides (tumors on the skin).
What is the side effect of cyclophosphamide?
Are there any guidelines on the use of cyclophosphamide tablets?
Several guidelines on this subject have been published. 1-8 There is no general agreement that all of the procedures recommended in the guidelines are necessary or appropriate. To minimize the risk of dermal exposure, always wear impervious gloves when handling bottles containing cyclophosphamide tablets.
What is the chemical name of cyclophosphamide?
Cyclophosphamide is a white crystalline powder with the molecular formula C7H15Cl2N2O2P • H2O and a molecular weight of 279.1. The chemical name for Cyclophosphamide is 2H-1,3,2-Oxazaphosphorin-2-amine, N,N-bis(2-chloroethyl)tetrahydro-, 2-oxide, monohydrate, (±).
What are the side effects of cyclophosphamide in cystitis?
Discontinue Cyclophosphamide therapy in case of severe hemorrhagic cystitis. Urotoxicity (bladder ulceration, necrosis, fibrosis, contracture and secondary cancer) may require interruption of Cyclophosphamide treatment or cystectomy. Urotoxicity can be fatal. Urotoxicity can occur with short-term or long-term use of Cyclophosphamide.
Is cyclophosphamide toxic to humans?
Cyclophosphamide is genotoxic [see Nonclinical Toxicology (13.1)]. Secondary malignancies (urinary tract cancer, myelodysplasia, acute leukemias, lymphomas, thyroid cancer, and sarcomas) have been reported in patients treated with Cyclophosphamide-containing regimens.