What is an indolent tumor?
An indolent tumor is slow-growing, which is generally a good sign. For example, an indolent prostate tumor is typically treated with a wait-and-see approach. An indolent wound, on the other hand, is a slow-healing wound. In the case of an indolent wound, more aggressive treatment may be required.
What does phosphorylation mean?
Listen to pronunciation. (fos-FOR-ih-LAY-shun) A process in which a phosphate group is added to a molecule, such as a sugar or a protein.
What does indolent mean medically?
Medical Definition of indolent 1 : causing little or no pain an indolent tumor. 2a : growing or progressing slowly leprosy is an indolent infectious disease. b : slow to heal an indolent ulcer.
Why are some cancers indolent?
This detection of indolent disease is mainly due to the inherent tendency of all screening tests to preferentially detect slower growing cancers because more rapidly growing cancers are more likely to present between screens. Indolent disease might account for 15–75% of all cancers, depending on organ type.
What is phosphorylation used for?
Phosphorylation plays critical roles in the regulation of many cellular processes including cell cycle, growth, apoptosis and signal transduction pathways. Phosphorylation is the most common mechanism of regulating protein function and transmitting signals throughout the cell.
What happens in phosphorylation?
Phosphorylation is the process through which a phosphate group is transferred from one molecule to a protein, usually within a biological system. A protein being phosphorylated is like drinking a Red Bull before a workout – it prepares a molecule for some specialized task.
How long can you live with indolent lymphoma?
Life expectancy for this disease The average age of those who are diagnosed with indolent lymphoma is about 60. It affects both men and women. The average life expectancy after diagnosis is approximately 12 to 14 years.
What is chronic indolent infection?
Chronic or indolent invasive fungal sinusitis occurs predominantly in immunocompetent and atopic hosts. It is a slowly progressive disease characterized by granulomatous chronic infection that extends beyond the sinus walls.
What does phosphorylation produce?
Oxidative phosphorylation is the process where energy is harnessed through a series of protein complexes embedded in the inner-membrane of mitochondria (called the electron transport chain and ATP synthase) to create ATP.
What is phosphorylation quizlet?
phosphorylation. the process by which a kinase or other enzyme causes a substrate molecule to gain a phosphate group from ATP or another phosphate donor. This is a transesterification process that produces a phosphorylated substrate and ADP.
What is phosphorylated in glycolysis?
In the first step of glycolysis, the glucose ring is phosphorylated. Phosphorylation is the process of adding a phosphate group to a molecule derived from ATP. As a result, at this point in glycolysis, 1 molecule of ATP has been consumed.
What is the treatment for indolent lymphoma?
Targeted therapy may be offered for relapsed or refractory indolent B-cell lymphomas. Rituximab is used most often and can be given alone or as part of combination chemotherapy. Other drugs, such as ibritumomab (Zevalin), may be given if chemotherapy and rituximab no longer seem to be working.
What are the 3 types of phosphorylation?
Many types of molecules can undergo phosphorylation and dephosphorylation. Three of the most important types of phosphorylation are glucose phosphorylation, protein phosphorylation, and oxidative phosphorylation. Glucose Phosphorylation. Glucose and other sugars are often phosphorylated as the first step of their catabolism.
Is the phosphorylation of eIF4E independent of extracellular stimuli?
This phosphorylation event appears to be relatively independent of extracellular stimuli. The second step, which is activated by extracellular stimuli, is the phosphorylation of the sites located carboxy-terminal to the eIF4E-binding site, including Ser-65 and Thr-70 (A.-C. Gingras, B. Raught, and S.P. Gygi, unpubl.).
How is 4E-BP1 phosphorylated in vivo?
4E-BP1 is phosphorylated in vivo on multiple residues (Fadden et al. 1997; Heesom et al. 1998). However, the order of phosphate addition and the functional significance of each phosphorylation event regarding the interaction of 4E-BP1 with eIF4E is unknown.
What is a phosphorylase?
In more general terms, phosphorylases are enzymes that catalyze the addition of a phosphate group from an inorganic phosphate (phosphate + hydrogen) to an acceptor, not to be confused with a phosphatase (a hydrolase) or a kinase (a phosphotransferase ).