What is L-selectin ligand?
L-selectin, also known as CD62L, is a cell adhesion molecule found on the cell surface of leukocytes and the preimplantation embryo. It belongs to the selectin family of proteins, which recognize sialylated carbohydrate groups containing a Sialyl LewisX (sLeX) determinant.
Do neutrophils express L-selectin?
L-selectin is a type I transmembrane cell adhesion molecule expressed on most circulating leukocytes, including neutrophils.
Where is L-selectin expressed?
leukocytes
L-selectin is constitutively expressed on the tips of the microvilli of most leukocytes, including neutrophils, eosinophils, monocytes, and naïve T and B cells, as well as on the surface of some activated T cells and memory T cells upon activation by appropriate stimuli including chemotactic factors.
Is selectin a receptor?
Selectins Are Carbohydrate-Binding Adhesion Receptors. The selectins, as indicated by their name, participate exclusively in heterophilic cell-cell binding because they have a lectin-like domain at their NH2 terminus that binds to specific carbohydrate residues on the opposite cell surface (see Fig. 7–1).
What is L-selectin shedding?
L-selectin contributes to physiologic leukocyte rolling 2 and is rapidly shed from the surface of leukocytes upon activation 3. TNF-α converting enzyme is involved in PMA-induced shedding of L-selectin in murine fetal thymocytes 4; however, the L-selectin sheddase on granulocytes has not yet been identified.
Is E-selectin a protein?
The human and mouse E-Selectin proteins share 81% amino acid similarity. E-Selectin mediates the attachment of flowing leukocytes to the blood vessel wall during inflammation by binding to E-Selectin ligands on leukocytes.
What are selectin receptors?
What does E-selectin stand for?
E-selectin, also known as CD62 antigen-like family member E (CD62E), endothelial-leukocyte adhesion molecule 1 (ELAM-1), or leukocyte-endothelial cell adhesion molecule 2 (LECAM2), is a selectin cell adhesion molecule expressed only on endothelial cells activated by cytokines.