What is the pathogenicity of chlamydia?
Disease pathogenesis due to Chlamydia trachomatis is a complicated process that involves: (1) exposure to the organism and infectivity; (2) survival within the host cell; (3) virulence associated with specific strain types; (4) innate and acquired immunity, and (5) host genetic susceptibility to infection and disease.
What are serovars of chlamydia?
Chlamydia trachomatis serovars A-C infect conjunctival epithelial cells and untreated infection can lead to blindness. D-K infect genital tract epithelial cells resulting in pelvic inflammatory disease, ectopic pregnancy, and sterility while L1-L3 infect epithelial cells and macrophages, causing an invasive infection.
What is the replicative form of chlamydia?
Chlamydia trachomatis is the most common cause of bacterial sexually transmitted infection. It produces an unusual intracellular infection in which a vegetative form, called the reticulate body (RB), replicates and then converts into an elementary body (EB), which is the infectious form.
Is Chlamydia trachomatis pathogenic?
Chlamydia trachomatis is the most common bacterial sexually transmitted pathogen worldwide. Infection can result in serious reproductive pathologies, including pelvic inflammatory disease, ectopic pregnancy, and infertility, in women.
What is the pathogenesis of gonorrhea?
Pathogenesis of Neisseria gonorrhoeae and the Host Defense in Ascending Infections of Human Fallopian Tube. Neisseria gonorrhoeae is an obligate human pathogen that causes mucosal surface infections of male and female reproductive tracts, pharynx, rectum, and conjunctiva.
What is Biovar and serovar?
A biovar is a variant prokaryotic strain that differs physiologically or biochemically from other strains in a particular species. Morphovars (or morphotypes) are those strains that differ morphologically. Serovars (or serotypes) are those strains that have antigenic properties that differ from other strains.
What is the pathogenesis of trachoma?
Pathophysiology: Blindness from trachoma is due to recurrent episodes of active infection over months to years. The initial infection is confined to the conjunctival epithelium and triggers an immune response presenting as conjunctival follicles.
What is meant by virulence factors?
Virulence is described as an ability of an organism to infect the host and cause a disease. Virulence factors are the molecules that assist the bacterium colonize the host at the cellular level. These factors are either secretory, membrane associated or cytosolic in nature.
Is Chlamydia trachomatis aerobic or anaerobic?
Chlamydia trachomatis is part of the chlamydophila genus. These bacteria are gram-negative, anaerobic, intracellular obligates that replicate within eukaryotic cells.
Is chlamydia a Diplococci?
The Centers for Disease Control (CDC) considers gonorrhea, chlamydia, and syphilis, (caused by the gram-negative diplococcus Neisseria gonorrhoeae, the obligate intracellular bacteria Chlamydia trachomatis, and the spirochete Treponema pallidum, respectively) to be reportable organisms.