What are the properties and characteristics of Taxol?
Abstract. Paclitaxel is a diterpenoid pseudoalkaloid, isolated from Taxus brevifolia, and is largely used as an antitumoral drug. The formulation of paclitaxel known as Taxol® employs a mixture of Cremophor EL and dehydrated ethanol, due the low drug water solubility.
What is the brand name for paclitaxel?
Nab-paclitaxel is a chemotherapy drug and is also known by its brand name, Abraxane.
What is the MOA of paclitaxel?
Mechanism of action of paclitaxel. Paclitaxel targets microtubules. At high concentration, PTX causes mitotic arrest at G2/M phase whereas at low concentration, apoptosis is induced at G0 and G1/S phase either via Raf-1 kinase activation or p53/p21 depending on the dose concentration.
What are the ingredients in paclitaxel?
Each vial contains Paclitaxel, PEG-35 castor oil, anhydrous citric acid and absolute ethanol. Paclitaxel is a natural product with antitumour activity. It is a white to off white crystalline powder that is highly lipophilic and insoluble in water.
What is paclitaxel used for?
Paclitaxel (with polyoxyethylated castor oil) is used along or along with other chemotherapy medications to treat breast cancer, ovarian cancer (cancer that begins in the female reproductive organs where eggs are formed), and non-small cell lung cancer (NSCLC).
What type of molecule is paclitaxel?
Paclitaxel is a tetracyclic diterpenoid isolated originally from the bark of the Pacific yew tree, Taxus brevifolia. It is a mitotic inhibitor used in cancer chemotherapy. Note that the use of the former generic name ‘taxol’ is now limited, as Taxol is a registered trade mark.
What classification is paclitaxel?
Paclitaxel is in a class of medications called antimicrotubule agents. It works by stopping the growth and spread of cancer cells.
Is paclitaxel a natural product?
Paclitaxel, the most well-known natural-source cancer drug in the United States, is derived from the bark of the Pacific yew tree (Taxus brevifolia) and is used in the treatment of breast, lung, and ovarian cancer, as well as Kaposi’s sarcoma.
What is the target of paclitaxel?
Paclitaxel is one of several cytoskeletal drugs that target tubulin. Paclitaxel-treated cells have defects in mitotic spindle assembly, chromosome segregation, and cell division.
What class of drug is paclitaxel?
What is the chemical formula of paclitaxel?
C47H51NO14Paclitaxel / Formula
How effective is paclitaxel?
Dose-dense paclitaxel (paclitaxel given on a frequent or weekly schedule) has been shown to be a safe and effective treatment of metastatic breast cancer, inducing tumor responses in more than 50% of patients with metastatic breast cancer.