Which drugs are metabolized by CYP2B6?
Drugs metabolized mainly by CYP2B6 include artemisinin, bupropion, cyclophosphamide, efavirenz, ketamine, and methadone. CYP2B6 is one of the most polymorphic CYP genes in humans and variants have been shown to affect transcriptional regulation, splicing, mRNA and protein expression, and catalytic activity.
What is a CYP2D6 test?
The xTAG® CYP2D6 Kit v3 is a device used to simultaneously detect and identify a panel of nucleotide variants found within the highly polymorphic CYP2D6 gene located on chromosome 22 from genomic DNA extracted from EDTA and citrate anticoagulated whole blood samples.
What is CYP2B6 * 6?
CYP2B6 (Cytochrome P450 Family 2 Subfamily B Member 6) is a Protein Coding gene. Diseases associated with CYP2B6 include Efavirenz, Poor Metabolism Of and Acute Frontal Sinusitis.
What is CYP2C19 testing?
This test helps determine if you may be less responsive to the drug clopidogrel because of your genetic makeup. This test detects genetic variation in the gene CYP2C19.
Who is a CYP2C19 poor metabolizer?
Individuals who carry 2 non-functional copies of the CYP2C19 gene are classified as CYP2C19 poor metabolizers. They have no enzyme activity and cannot activate clopidogrel via the CYP2C19 pathway, which means the drug will have no effect.
What does it mean to be a poor metabolizer?
Poor Metabolizer. A poor-metabolizing enzyme has very low activity. It is possible to have side effects even with a very low drug dose, because the enzyme is very slow to break down the drug. Rapid or Ultrarapid Metabolizers. These enzymes are very active, often breaking down drugs before they can have any effect.
What drugs are affected by CYP1A2?
CYP1A2 plays an important role in metabolism of drugs like clozapine, olanzapine, fluvoxamine, haloperidol, theophylline; biotransformation of endogenous compounds like melatonin, bilirubin, estrogens, procarcinogens, aflatoxin B1, and aromatic/heterocyclic amines as well as caffeine (Gunes and Dahl, 2008).
