What is on-target and off-target?
On-target refers to exaggerated and adverse pharmacologic effects at the target of interest in the test system. Off-target refers to adverse effects as a result of modulation of other targets; these may be related biologically or totally unrelated to the target of interest.
What is an on-target side effect?
On-target side effects refer to the pharmacodynamic effect on normal tissues that occurs when the target that’s being inhibited in the tumor is also being inhibited in the normal tissue.
What is target based discovery?
In the past three decades, target-based drug discovery (TDD) — in which the starting point is a defined molecular target that is hypothesized to have an important role in disease — has been the dominant approach to drug discovery in the pharmaceutical industry, driven by advances in molecular biology and genomics.
What is a synonym for off-target?
Off-target synonyms In this page you can discover 8 synonyms, antonyms, idiomatic expressions, and related words for off-target, like: mishit, mis-hit, goalwards, well-struck, goalward, 35-yard, unsighted and overhit.
What is another word for Off Target?
What is another word for off-target?
| off-center | askew |
|---|---|
| wide | adrift |
| astray | far-off |
| inaccurate | off-course |
| off the mark | stray |
What is an off target mutation?
Off-target effects can be defined as unintended cleavage and mutations at untargeted genomic sites showing a similar but not an identical sequence compared to the target site (Modrzejewski et al., 2019). It is not exactly known why the Cas9 protein cleaves some off-target sites and others not.
What is on target toxicity?
On-target toxicity is also referred to as mechanism-based toxicity. This type of adverse effect that results from pharmaceutical drug exposure is commonly due to interactions of the drug with its intended target. In this case, both the therapeutic and toxic targets are the same.
What are the types of drug toxicity?
The causes of drug toxicity can be organized in several ways and include mechanism-based (on-target) toxicity, immune hypersensitivity, off-target toxicity, and bioactivation/covalent modification.
What do the terms PDD and TDD stand for in pharma industries?
Phenotypic drug discovery (PDD) complements target-based drug discovery (TDD). PDD uses empirical, targetagnostic lead generation to identify pharmacologically active molecules and novel therapeutics which work through unprecedented drug mechanisms.