What is the formula for cisplatin?
[Pt(NH3)2Cl2]Cisplatin / Formula
What is the geometry of cisplatin?
Cisplatin (CAS No. 15663-27-1, MF-Cl2H6N2Pt; NCF-119875), cisplatinum, also called cis-diamminedichloroplatinum(II), is a metallic (platinum) coordination compound with a square planar geometry. It is a white or deep yellow to yellow-orange crystalline powder at room temperature.
What does cisplatin contain?
Cisplatin is used to treat various types of cancer. It is a chemotherapy drug that contains platinum. It is used to slow or stop cancer cell growth.
How does cisplatin work chemistry?
The Pt(II) complex cisplatin is used as an anticancer drug. Cisplatin prevents DNA replication in cancer cells by a ligand replacement reaction with DNA in which a bond is formed between platinum and a nitrogen atom on guanine.
What is the chemical formula for chemotherapy?
Chemistry: Plant derived agent, epipodophyllotoxin, molecular weight 588.6, chemical formula C29H32O13. Lipid soluble, supplied as solution with polyethylene glycol, polysulfate, benzyl alcohol, citric acid, ethyl alcohol. The pH of the clear yellow solution is 3 to 4.
What is cisplatin and Taxol?
Cisplatin and paclitaxel, also known as “cis/taxol,” is given to shrink tumors and decrease symptoms from cervical cancer. Cisplatin and paclitaxel for cervical cancer is not commonly given with the goal of cure.
Is cisplatin tetrahedral or square planar?
square planar
Although some students of organic chemistry may be accustomed to interpreting a tetracoordinate atom as a flattened tetrahedron, cisplatin has a square planar geometry. This shape minimizes repulsive interactions between electrons in the d orbitals.
Why is cisplatin square planar and not tetrahedral?
Notable examples include the anticancer drugs cisplatin (PtCl2(NH3)2). A square planar complex also has a coordination number of 4. The structure of the complex differs from tetrahedral because the ligands form a simple square on the x and y axes.
What is the other name for cisplatin?
Cisplatin is the generic name for the trade name drug Platinol® and Platinol®-AQ. In some cases, health care professionals may use the trade name Platinol® and Platinol®-AQ, or other names such as CDDP, when referring to the generic drug name cisplatin.
Which of the following is cisplatin?
Cisplatin or (SP-4-2)-diamminedichloridoplatinum(II) is one of the most potential and widely used drugs for the treatment of various solid cancers such as testicular, ovarian, head and neck, bladder, lung, cervical cancer, melanoma, lymphomas and several others.
How does cisplatin inhibit DNA replication?
Cisplatin binds covalently to DNA, which trigger inhibition of DNA replication, causing cell cycle arrest in the S/G2 phase32.
Is cisplatin organic or inorganic?
Unlike many cancer drugs, which are organic molecules with complex structures, cisplatin is an inorganic molecule with a simple structure. In designing and evaluating new cancer treatments, researchers use cisplatin as the gold standard against which new medicines are compared.