What does a conditioned place preference show?
Conditioned place preference (CPP) is a form of Pavlovian conditioning used to measure the motivational effects of objects or experiences. By measuring the amount of time an animal spends in an area that has been associated with a stimulus, researchers can infer the animal’s liking for the stimulus.
What is conditioned place aversion?
Conditioned Place Preference or Aversion In a Conditioned Place Preference task, the animal learns an association between an enviroment with distinctive cues and a positive reinforcer. It is often used as an animal model of the subjective effects of drugs.
What is locomotor sensitization?
Locomotor sensitization is a common and robust behavioral alteration in rodents whereby following exposure to abused drugs such as cocaine, the animal becomes significantly more hyperactive in response to an acute drug challenge.
What is the drug discrimination paradigm?
Drug discrimination is a behavioral paradigm in which animals learn to discriminate the effects of a substance from the properties produced by other drugs or by non-drug solutions.
Is conditioned place preference classical conditioning?
Conditioned place preference (CPP)/conditioned place aversion (CPA) is a behavioral paradigm largely based on the principles of classical (Pavlovian) conditioning.
What is behavioral sensitization?
Behavioral sensitization is the process whereby repeated, intermittent stimulant administration produces a progressively greater and enduring behavioral response.
What is a drug discrimination study?
DD models measure an animal’s ability to identify (“discriminate”) a particular dose of a particular drug, compared to either another dose or another drug, or vehicle only (e.g. saline in i.v. models). The behavior is differentially reinforced depending on the presence or absence of specific drug stimuli.
What is CCP conditioning?
The conditioned place preference paradigm is a standard preclinical behavioral model used to study the rewarding and aversive effects of drugs.
How does conditioning take place?
Classical conditioning is a form of learning whereby a conditioned stimulus (CS) becomes associated with an unrelated unconditioned stimulus (US) in order to produce a behavioral response known as a conditioned response (CR). The conditioned response is the learned response to the previously neutral stimulus.
How does classical conditioning take place?
Classical conditioning refers to learning that occurs when a neutral stimulus (e.g., a tone) becomes associated with a stimulus (e.g., food) that naturally produces a behaviour. After the association is learned, the previously neutral stimulus is sufficient to produce the behaviour.
How does the conditioned place preference protocol work?
The conditioned place preference protocol makes use of an apparatus that contains two or more compartments or areas. These two compartments are designed so that the animal can discriminate between them.
Does handling block expression of conditioned place aversion in mice?
^ Bechtholt, A.J., Gremel, C.M. & Cunningham, C.L. Handling blocks expression of conditioned place aversion but not conditioned place preference produced by ethanol in mice. Pharmacol. Biochem. Behav. 79, 739–744 (2004).
Are there genetic differences in cocaine-induced conditioned place preference in mice?
Cunningham, C.L., Dickinson, S.D., Grahame, N.J., Okorn, D.M. & McMullin, C.S. Genetic differences in cocaine-induced conditioned place preference in mice depend on conditioning trial duration. Psychopharmacology (Berl.) 146, 73–80 (1999).
Do humans have conditioned place preferences?
Humans have also been shown to develop conditioned place preferences; for example, people taking therapeutic doses of amphetamine develop a CPP for where they consumed the drug.