Is 27 alkaline phosphatase low?
The normal range of alkaline phosphatase in the blood is 20 to 140 U/L, although this can vary from lab to lab. Some labs set the range at 30 to 130 U/L. Children and pregnant women can have significantly higher levels of the enzyme in their blood [1]. Values under 30 U/L are usually considered low.
What does low bone alkaline phosphatase mean?
Low levels of alkaline phosphatase may indicate hypophosphatasia, a rare genetic disease that affects bones and teeth. Low levels may also be due to a deficiency of zinc or malnutrition. To learn what your results mean, talk to your health care provider.
What is a normal range of bone alkaline phosphatase?
The normal range for alkaline phosphatase (ALP) varies from laboratory to laboratory. One common reference range is from 44 to 147 international units per liter (IU/L), but some organizations recommend a range of 30 to 120 IU/L.
What is a concerning Alk Phos level?
ALP results are reported in units per liter (U/L). For men and women older than age 18, an ALP level between 44 and 147 U/L is considered normal. The normal range for children is higher than that for adults, especially for infants and teens because their bones are growing rapidly.
What are symptoms of low alkaline phosphatase?
Low ALP: Could it be HPP?
- Failure to thrive (in infants)
- Short stature.
- Bone and joint pain.
- Missed gross motor milestones (standing, sitting, crawling, turning over)
- Misshapen head, caused by craniosynostosis or chiari malformation.
- Brain fog.
Can low vitamin D cause low alkaline phosphatase?
Thus, vitamin D deficiency is usually accompanied by normal blood levels for calcium and phosphorus, high-normal or elevated levels of PTH, normal to elevated levels of total alkaline phosphatase, a low 24-hour urine calcium excretion rate, and low levels of total 25(OH)D.
What does alkaline phosphatase do in bone?
Bone ALP is a major regulator of bone mineralization. It hydrolyzes inorganic pyrophosphate which is a naturally occurring inhibitor of mineralization. Bone ALP also provides inorganic phosphate (from pyrophosphate and organic phosphomonoesters) for the synthesis of hydroxyapatite [7,8].
Is low alkaline phosphatase rare?
Low ALP is rare. It wouldn’t be unusual for a doctor to disregard a low ALP result. But if you have low ALP, you should be aware that in some people it is a sign of hypophosphatasia—HPP—a rare disease that affects bones and teeth.
When should I worry about low ALT?
Having a lower than normal ALT result is uncommon and usually isn’t a cause for concern. However, a lower than normal ALT level could indicate a vitamin B6 deficiency or chronic kidney disease.