What does Temra stand for?
Abbreviations: Tcm, central memory T cells; Tem, effector memory T cells; Temra, terminally differentiated effector memory T cells; Trm, resident memory T cells; Tfh, follicular helper memory T cells.
Where are CD4 markers found?
CD4 is found on the surface of immune cells such as T helper cells, monocytes, macrophages, and dendritic cells.
What is B220 marker?
B220 antigens represent a subset of mouse CD45 isoforms predominantly expressed on all B lymphocytes, including pro-, mature and activated B cells. The level of B220 antigen expression on the B cell lineage is developmentally regulated and this antibody is commonly used as a B cell marker.
What is CD27 a marker for?
CD27+ B cells are larger cells with abundant cytoplasm carrying somatic hypermutation, and have an ability to produce immunoglobulin, indicating that CD27 is a memory marker of B cells. The ligation of CD27 yields crucial signals that positively control the entry of B cells into the pathway to plasma cells.
What is the function of CD127?
CD127 (Interleukin-7, IL-7) is a glycoprotein involved in the regulation of lymphopoiesis. The response of cells to CD127 is dependent on the presence of the interleukin 7 receptor (IL7R); the active receptor is an alpha/gamma chain heterodimer.
What is the function of CD256 and CD257?
Receptor for CD256 and CD257, activates NFkB and JNK. Promotes B-cell survival and plays a role in the regulation of humoral immunity. T follicular helper cells and antigen-presenting cells. When bound to receptor BTLA (CD272), regulates inhibition and costimulation of several key players in the immune system.
What is the function of CD132 complex in cytokines?
Complexes with other cell surface proteins to form receptors for the cytokines IL2, IL4, IL7, IL9, and IL15. Acting through the CD132 containing complexes, these cytokines regulate lymphocyte development and activation. Hematopoietic stem cell subsets, epithelial, endothelial and neural cell precursors.
Which autoimmune diseases are associated with CD127 dysfunction?
Diseases associated with CD127 dysfunction include severe combined immunodeficiency and T cell negative/B cell negative/NK positive severe combined immunodeficiency. For Research Use Only.