What is a Homotrimer cluster?
A homotrimer is a protein which is composed of three identical units of polypeptide.
How many amino acids are in a Homotrimer?
261 amino acids
PCNA from H. sapiens is a homotrimer of subunits encoded by the PCNA gene with each subunit 261 amino acids in length.
How many subunits would a Homotrimer have?
three identical
2 Structure. The overall architecture of the enzyme is organized as a homotrimer where the three identical subunits are tightly associated around a central channel of 5–6 Å in a threefold axis symmetry.
Is spike protein homotrimer?
The SARS-CoV-2 spike protein is a homotrimer composed of three monomers (chains A, B, and C; Figure 1a). Each monomeric protein contains an N-terminal ACE2 binding domain (receptor binding domain; RBD), a central helix/heptad repeat, and a C-terminal region that interacts with the plasma membrane [18].
What is the function of spike glycoprotein?
Like other coronaviruses, the SARS-CoV-2 genome encodes spike (S) glycoproteins, which protrude from the surface of mature virions. The S glycoprotein plays essential roles in virus attachment, fusion and entry into the host cell.
What is a trimeric complex?
In biochemistry, a protein trimer is a macromolecular complex formed by three, usually non-covalently bound, macromolecules like proteins or nucleic acids. A homotrimer would be formed by three identical molecules.
What does glycoprotein mean?
Definition of glycoprotein : a conjugated protein in which the nonprotein group is a carbohydrate.
What are some functions of glycoproteins?
Glycoproteins function in the structure, reproduction, immune system, hormones, and protection of cells and organisms. Glycoproteins are found on the surface of the lipid bilayer of cell membranes.
What is a peptide group?
peptide bond n. The chemical bond between carboxyl groups and amino groups of neighboring amino acids, forming an amide group and constituting the primary linkage of all protein structures.
What is a trimeric?
tri·mer. (trī′mər) n. A chemical compound or molecule consisting of three identical simpler molecules.
What is homotrimer?
A Homotrimer is a protein which is composed of three identical units of polypeptide. How to pronounce homotrimer? How to say homotrimer in sign language? We’re doing our best to make sure our content is useful, accurate and safe.
What is the difference between homotrimer and Vegi?
Homotrimer; 17.5 kDa form is secreted, 26 kDa form is membrane-anchored; VEGI (V ascular E ndothelial G rowth I nhibitor, not listed here) is a novel member of the TNF family expressed predominantly in endothelial cells 2. Also known as CD70 3.
Is TNF trimeric or heteromeric?
Paralogous proteins in the TNF superfamily are also trimeric, although some are heteromers [e.g., lymphotoxinβ (LTβ)], and most remain stably attached to the cell membrane. In this regard, the sole exception is lymphotoxinα (LTα), which is entirely secreted.
How is Maltoporin organized as a homotrimer?
Maltoporin is organized as a homotrimer (molecular mass of the monomer: 47 kDa), with each monomer providing a distinct maltodextrin-binding site, which is crucial for the facilitated diffusion process (Luckey and Nikaido, 1980 ).