What is THP protecting group?
The tetrahydropyranyl ether is a useful protecting group for the protection of alcohols and phenols, offering stability towards strongly basic reaction conditions, organometallics, hydrides, acylating reagents and alkylation reagents.
What are protecting groups in organic chemistry?
A protecting group (PG) is a molecular framework that is introduced onto a specific functional group (FG) in a poly-functional molecule to block its reactivity under reaction conditions needed to make modifications elsewhere in the molecule.
What is Tetrahydropyran used for?
2-Tetrahydropyranyl (THP-) ethers derived from the reaction of alcohols and 3,4-dihydropyran are commonly used as protecting groups in organic synthesis. Furthermore, a tetrahydropyran ring system, i.e., five carbon atoms and an oxygen, is the core of pyranose sugars, such as glucose.
What are protecting groups used for?
Protecting groups are used in synthesis to temporarily mask the characteristic chemistry of a functional group because it interferes with another reaction. A good protecting group should be easy to put on, easy to remove and in high yielding reactions, and inert to the conditions of the reaction required.
What is PMB chemistry?
p-Methoxybenzyl ether (PMB) – Removed by acid, hydrogenolysis, or oxidation. Methylthiomethyl ether – Removed by acid. Pivaloyl (Piv) – Removed by acid, base or reductant agents. It is substantially more stable than other acyl protecting groups.
Is hydroxyl and alcohol the same?
Alcohols are organic compounds that are composed of hydroxyl groups. The main difference between hydroxyl and alcohol is that hydroxyl is a functional group whereas alcohol is an organic compound.
What does the hydroxyl functional group do?
2.5 Hydroxyl Groups They readily participate in hydrogen bonding, generating either a net positively or negatively charged ion. This group can also participate in chemical reactions to link molecules together, forming chains of sugars or fatty acids.
What is the IUPAC name of THP?
Tetrahydropyran ( THP) is the organic compound consisting of a saturated six-membered ring containing five carbon atoms and one oxygen atom. It is named by reference to pyran, which contains two double bonds, and may be produced from it by adding four hydrogens. In 2013, its preferred IUPAC name was established as oxane.
What is THP used to treat?
THP is given to shrink tumors and slow the progression of the disease, which can decrease symptoms of breast cancer and possibly extend life. THP is not commonly given with the goal of cure. Tap along the timeline to move to different parts of the audio file.
How does THP work to kill cancer cells?
How THP Works. Docetaxel works by damaging the structure or the “skeleton” that supports cancer cells. This stops the cancer cells from growing and dividing. Also called Herceptin. A monoclonal antibody that binds to HER2 (human epidermal growth factor receptor 2), and can kill HER2-positive breast cancer cells.
What chemicals are found in TPH?
Some chemicals that may be found in TPH are hexane, jet fuels, mineral oils, benzene, toluene, xylenes, naphthalene, and fluorene, as well as other petroleum products and gasoline components. However, it is likely that samples of TPH will contain only some, or a mixture, of these chemicals. (Source Exit)