What is high Hyperdiploid?
High hyperdiploidy (51–65 chromosomes, HeH) is an established genetic subtype of B-cell precursor acute lymphoblastic leukaemia (BCP-ALL), which is associated with a favourable prognosis, especially in children.
What is Hyperdiploidy leukemia?
High hyperdiploid childhood acute lymphoblastic leukemia is characterized by multiple chromosomal gains. Recent results show that this subtype harbors relatively few genetic abnormalities besides the extra chromosomes, which appear to arise early and are likely the main driver event.
What is double trisomy?
The double trisomies included chromosomes 2, 4, 5, 7, 8, 12, 13, 14, 15, 16, 17, 18, 20, 21, and 22. The chromosomes that were trisomic in more than one double trisomy case were numbers 16 (8 cases), 8 (5 cases), 15 (4 cases), 2, 13, and 21 (3 cases each), and 5, 7, 14, 18, 20, 22, and X (2 cases).
What does a normal karyotype look like?
Females have two X chromosomes, while males have one X and one Y chromosome. A picture of all 46 chromosomes in their pairs is called a karyotype. A normal female karyotype is written 46, XX, and a normal male karyotype is written 46, XY.
What is Hypoploidy?
Definition of hypoploid : having a chromosome number slightly less than an exact multiple of the monoploid number.
How many chromosomes are in a hyperdiploid karyotype?
In 80 patients (80/278, 28.8%) the cytogenetic analysis detected a hyperdiploid karyotype >50 chromosomes, whereas the remaining patients (n=12) could be related to other ploidy subgroups, ie hyperdiploidy with 47-50 chromosomes, haploidy, triploidy/tetraploidy.
Can fish detect hyperdiploid karyotypes?
Only one patient was not identified as having a hyperdiploid karyotype with our combination of DNA probes. Our results indicate that FISH is a feasible and quick screening method for the detection of hyperdiploid karyotypes (>50 chromosomes) and other ploidy subgroups.
What do we know about hyperdiploid karyotypes in acute myeloid leukemia (AML)?
Chromosome gain is frequent in acute myeloid leukemia (AML) and is counted alongside structural abnormalities when determining karyotype complexity. However, there are few studies investigating the cytogenetic profile and outcome of patients with a hyperdiploid karyotype (49-65 chromosomes, HK).
What is a high hyperdiploid karyotype in B-cell lymphoma?
Since the 1980s, it has been appreciated that 25% to 30% of B-cell ALL cases have a “high” hyperdiploid karyotype (generally defined as >50-67 chromosomes) and that this subset has an unusually good prognosis (reviewed by Paulsson and Johansson 1 ). This feature has been used routinely to stratify patients into treatment groups.