What is the PPARGC1A gene?
PPARGC1A (PPARG Coactivator 1 Alpha) is a Protein Coding gene. Diseases associated with PPARGC1A include Amyotrophic Lateral Sclerosis 1 and Type 2 Diabetes Mellitus. Among its related pathways are Metabolism and Circadian Clock.
Is pgc1a a transcription factor?
PGC-1α performs all these tasks by regulating the activity of a large number of transcription factors, including, among others, peroxisome proliferator-activated receptor (PPAR) γ (4), PPARα (5), estrogen receptor–related α (ERRα) (6), FoxO1 (7), hepatocyte nuclear factor 4α (HNF4α) (8), and nuclear respiratory factor …
What activates is PGC 1 alpha?
During fasting, the expression of PGC-1α is activated by glucagon and catecholamines via the stimulation of the cAMP pathway and the CREB transcription factor. PGC-1α then coactivates a variety of transcription factors such as hepatic nuclear factor-4α, glucocorticoid receptor, and forkhead box O1 (FOXO1).
What activates pgc1?
PGC1A gene expression is activated in liver by fasting (50, 70) and glucocorticoids (72), and it is now recognized that it regulates hepatic gluconeogenesis (31, 50, 70, 71).
Why is mitochondrial biogenesis important?
Mitochondrial biogenesis helps the cell to renew the mitochondrial network and, consequently, to improve mitochondrial function, slowing down the cascade of damage caused by mitochondrial dysfunction (one of the nine hallmarks of aging).
What activates PGC 1alpha?
What does PGC 1α stand for?
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) is a protein that in humans is encoded by the PPARGC1A gene. PPARGC1A is also known as human accelerated region 20 (HAR20). It may, therefore, have played a key role in differentiating humans from apes.
What is the function of PGC 1α?
PGC-1α is a transcriptional coactivator that regulates the genes involved in energy metabolism. It is the master regulator of mitochondrial biogenesis. This protein interacts with the nuclear receptor PPAR-γ, which permits the interaction of this protein with multiple transcription factors.
How does PGC-1α regulate mitochondrial biogenesis?
PGC-1α provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor causing slow-twitch rather than fast-twitch muscle fiber types. Endurance exercise has been shown to activate the PGC-1α gene in human skeletal muscle.
What is the role of PGC1α in the pathophysiology of kidney disease?
^ Tran MT, Zsengeller ZK, Berg AH, Khankin EV, Bhasin MK, Kim W, Clish CB, Stillman IE, Karumanchi SA, Rhee EP, Parikh SM (2016). “PGC1α drives NAD biosynthesis linking oxidative metabolism to renal protection”.
What is the function of the spleen?
The spleen is a small organ inside your left rib cage, just above the stomach. It’s part of the lymphatic system (which is part of the immune system). The spleen stores and filters blood and makes white blood cells that protect you from infection. Many diseases and conditions can affect how the spleen works. A ruptured (torn) spleen can be fatal.