What is the structure of triclosan?
C12H7Cl3O2Triclosan / Formula
What functional groups are in triclosan?
Triclosan (2,4,4′ –trichloro-2′-hydroxydiphenyl ether) is a chlorinated aromatic compound. Its functional groups include both phenols and ethers. It is used as a synthetic broad-spectrum antimicrobial agent. Triclosan was first registered as a pesticide in 1969.
What is the mechanism of action of triclosan?
The mode of action of triclosan involves blocking of lipid biosynthesis by binding with enoyl–acyl carrier protein reductase enzyme (ENR), which prevents the fatty acid synthesis required for lipid production in the microbe (Levy et al., 1999; Russell, 2004).
What are the physical properties of triclosan?
Triclosan (2,4,4′-trichloro-2′-hydroxydiphenyl ether) is a phenoxyphenol compound that has been principally considered as an antibacterial and antifungal agent [26]. Triclosan has a very low aqueous solubility of 0.012 g/L at 20 °C [43] .
What is triclosan?
What Is Triclosan? Triclosan is an ingredient added to many consumer products intended to reduce or prevent bacterial contamination. It is added to some antibacterial soaps and body washes, toothpastes, and some cosmetics—products regulated by the U.S. Food and Drug Administration (FDA).
What is another name for triclosan?
In personal care products, look for triclosan and its alternative names: Irgasan DP-300, Lexol 300, Ster-Zac, Cloxifenolum. It also has a close cousin called triclocarban. In plastics and clothing, look for triclosan and its alternative name Microban.
Is triclosan an organic compound?
Structure: This organic compound is a white powdery solid with a slight aromatic/phenolic odour. It is a chlorinated aromatic compound that contains both ether and phenol functional groups.
Is triclosan bactericidal or bacteriostatic?
bacteriostatic
Triclosan is bacteriostatic at low concentrations, but higher levels are bactericidal (Suller and Russell 1999, 2000). At sublethal concentrations, it acts by inhibiting the activity of the bacterial enoyl-acyl carrier protein reductase (FabI), a critical enzyme in bacterial fatty acid biosynthesis (Heath et al.
What is the chemical name for triclosan?
5-chloro-2-(2,4-dichlorophenoxy)phenolTriclosan / IUPAC ID
Its International Union of Pure and Applied Chemistry (IUPAC) name is 5-Chloro-2-(2,4-dichlorophenoxy)phenol. Triclosan is regulated by both the EPA and FDA.
Why is triclosan used?
Triclosan is an ingredient added to many consumer products intended to reduce or prevent bacterial contamination. It is added to some antibacterial soaps and body washes, toothpastes, and some cosmetics—products regulated by the U.S. Food and Drug Administration (FDA).
Is triclosan a chemical?
Triclosan, an antibacterial and antimicrobial chemical, has been used in personal care products and as a pesticide for decades.
How does triclosan inhibit bacterial growth?
At high concentrations, triclosan works by interfering with the outer membrane that protects bacteria, making it permeable so that triclosan can penetrate it and kill the microorganism. At lower concentrations, triclosan attacks several targets.
What is triclosan made of?
Triclosan is a polychloro phenoxy phenol with antibacterial and antifungal activity. Triclosan is added to toothpastes to prevent gingivitis and has been added to many household products for its topical antibiotic activity. 5-chloro-2- (2,4-dichlorophenoxy)phenol Computed by Lexichem TK 2.7.0 (PubChem release 2021.05.07)
What is the mechanism of action of ENR-NAD +-triclosan?
Mechanism of action. This results in the formation of a stable, ternary complex of ENR-NAD + -triclosan, which is unable to participate in fatty acid synthesis. Fatty acids are necessary for building and reproducing cell membranes. Humans do not have an ENR enzyme and thus are not affected by this mode of action.
What is the structure of triclosan sulfate?
Triclosan sulfate belongs to the class of organic compounds known as diphenylethers. These are aromatic compounds containing two benzene rings linked to each other through an ether group. Triclosan sulfate is considered to be a practically insoluble (in water) and relatively neutral molecule.
What is the role of triclosan in antibacterial use?
Triclosan is an active antibacterial in underarm deodorants and is used as an antibacterial component of plastic mattress covers (4). (1) O’Neil MJ, ed; The Merck Index. 15th ed., Cambridge, UK: Royal Society of Chemistry, p. 1789 (2013) (2) Daughton CG, Ternes TA; Environ Health Perspect 107: 907-38 (1999) (3) Pader M; Dentifrices.