What is the toxicity of cisplatin?
The major toxicities of a cisplatin overdose include nausea and vomiting, renal insufficiency, electrolyte abnormalities, myelosuppression, ototoxicity, peripheral neuropathy, hepatotoxicity and retinopathy. Diarrhoea, pancreatitis, seizures and respiratory failure have also been reported.
When should you not give cisplatin?
A repeat course of cisplatin (cisplatin injection) should not be given until the serum creatinine is below 1.5 mg/100 mL, and/or the BUN is below 25 mg/100 mL. A repeat course should not be given until circulating blood elements are at an acceptable level (platelets ≥ 100,000/mm3,WBC ≥ 4,000/mm3).
Is cisplatin the strongest chemo drug?
Presently, cisplatin is one of the most powerful chemotherapeutic drugs used for the treatment of ovarian cancer; even though resistance is typical [20]. In ovarian germ cell cancer, the use of cisplatin brings about high response rates [21].
What is the half life of cisplatin?
It is soluble in water or saline at 1 mg/mL and in dimethylformamide at 24 mg/mL. It has a melting point of 207° C. with a terminal half-life of 36 to 47 days. platinum is excreted beyond 24 hours post-infusion and most of the platinum excreted in the urine in 24 hours is excreted within the first few hours.
How do you reduce nephrotoxicity of cisplatin?
The standard approach for prevention of CIN is the administration of lower doses of cisplatin in combination with full intravenous hydration prior and after cisplatin administration. Cisplatin-induced oxidative stress in the kidney may be prevented by natural antioxidant compounds.
Can you drink alcohol on cisplatin?
Avoid drinks with caffeine or alcohol. You may have 1 cup (8 ounces) of caffeinated coffee or tea per day.
Does cisplatin cross the blood brain barrier?
Cisplatin doesn’t readily cross the blood-brain barrier. Drug is extensively and irreversibly bound to plasma proteins and tissue proteins.
Can I drink alcohol with cisplatin?
What is the most neurotoxic chemo?
Among the platinum compounds in clinical use, cisplatin is the most neurotoxic, inducing mainly sensory neuropathy of the upper and lower extremities.