What is the use of alefacept?
Alefacept is the first biological agent approved by the US Food and Drug Administration (FDA) for the treatment of moderate to severe chronic plaque psoriasis. It is a full human fusion protein binding to CD2 on T cells.
Is Alefacept still available?
Alefacept is no longer available. Astellas Pharma U.S. Inc. (Astellas) voluntarily discontinued the promotion, manufacturing, distribution and sales of Amevive®.
What is the brand name for ustekinumab?
Stelara is a brand-name prescription medication. It’s approved by the Food and Drug Administration (FDA) to treat: Moderate to severe plaque psoriasis. Stelara is used to treat this type of psoriasis in adults and children ages 6 years and older.
What is the couse of psoriasis?
Common psoriasis triggers include: Infections, such as strep throat or skin infections. Weather, especially cold, dry conditions. Injury to the skin, such as a cut or scrape, a bug bite, or a severe sunburn.
What is ustekinumab made from?
Ustekinumab was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. Ustekinumab binds to the p40 subunit common to IL-12 and IL-23 and prevents their interaction with the IL-12 receptor β1 subunit of the IL-12 and IL-23 receptor complexes.
Is Alefacept a biologic?
Alefacept, developed by Biogen, is the first biologic medicine approved to treat psoriasis.
What are the side effects of ustekinumab?
Common side effects of STELARA® include: nasal congestion, sore throat, and runny nose, upper respiratory infections, fever, headache, tiredness, itching, nausea and vomiting, redness at the injection site, vaginal yeast infections, urinary tract infections, sinus infection, bronchitis, diarrhea, stomach pain, and …
What class of drug is ustekinumab?
Ustekinumab injection is in a class of medications called monoclonal antibodies. It works by stopping the action of certain cells in the body that cause the symptoms of plaque psoriasis, psoriatic arthritis, Crohn’s disease, and ulcerative colitis.
What is alefacept used to treat?
Notified of marketing changes. Alefacept is a recombinant fusion protein that binds CD2 and is used treat moderate to severe plaque psoriasis.
What is the molecular weight of alefacept?
Alefacept is produced by recombinant DNA technology in a Chinese Hamster Ovary (CHO) mammalian cell expression system. The molecular weight of alefacept is 91.4 kilodaltons. AMEVIVE® is supplied as a sterile, white-to-off-white, preservative-free, lyophilized powder for parenteral administration.
What happened to alefacept?
Due to availability of better tolerated and more efficacious molecules for psoriasis, alefacept was withdrawn from use by its sponsor in 2011. ^ “Archived copy”. Archived from the original on 2018-10-13.
Can alefacept be used to treat influenza A and B?
The therapeutic efficacy of Influenza A virus A/Victoria/210/2009 X-187 (H3N2) hemagglutinin antigen (formaldehyde inactivated) can be decreased when used in combination with Alefacept. The therapeutic efficacy of Influenza B virus B/Brisbane/60/2008 antigen (formaldehyde inactivated) can be decreased when used in combination with Alefacept.