What kind of lineage give arise to dendritic cells?
DC and monocyte lineages originate from a common progenitor, the monocyte and dendritic cell progenitor (MDP). The two cell types diverge when MDPs give rise to monocytes and committed DC progenitors (CDPs) in the bone marrow.
Where are Langerhan cells?
Langerhans cells (LCs) reside in the epidermis as a dense network of immune system sentinels. These cells determine the appropriate adaptive immune response (inflammation or tolerance) by interpreting the microenvironmental context in which they encounter foreign substances.
What is the origin of dendritic cell?
Dendritic cells (DCs) are uniquely potent in orchestrating T cell immune response, thus they are indispensable immune sentinels. They originate from progenitors in the bone marrow through hematopoiesis, a highly regulated developmental process involving multiple cellular and molecular events.
Do dendritic cells arise only from myeloid lineage?
DCs were originally considered to be myeloid cells, but recent findings have demonstrated that DCs can develop not only from myeloid- but also from lymphoid-committed progenitors. The common feature of the progenitors capable of developing into DCs is the surface expression of Flt3 receptor.
How dendritic cells are formed?
Formation of immature cells and their maturation. Dendritic cells are derived from hematopoietic bone marrow progenitor cells. These progenitor cells initially transform into immature dendritic cells. These cells are characterized by high endocytic activity and low T-cell activation potential.
Do all dendritic cells express CD11c?
CD11c is commonly used as mouse DC marker. However, CD11c is not restricted to DCs, but also expressed by other immune cells, such as macrophages in the alveoli (Gonzalez-Juarrero et al., 2003) and adipose tissues (Brake et al., 2006). In humans, both monocytes and dendritic cells express CD11c (Collin et al., 2012).
What is the difference between Langerhans and dendritic cells?
Dendritic cells (DCs)3 are professional APCs that play a crucial role in activating adaptive immune responses. Langerhans cells (LCs) are a subset of immature DCs that reside in the epidermis. LCs are distinguished from other DCs by the presence of cytoplasmic organelles, known as Birbeck granules (1).