What cancer produces PTHrP?
Parathyroid hormone-related protein (or PTHrP) is a protein member of the parathyroid hormone family secreted by mesenchymal stem cells. It is occasionally secreted by cancer cells (breast cancer, certain types of lung cancer including squamous-cell lung carcinoma).
How does lymphoma cause hypercalcaemia?
Introduction: The etiology of hypercalcemia in non-Hodgkin lymphoma (NHL) has been most often attributed to either elevated serum levels of 1,25-dihydroxycholecalciferol (calcitriol) or parathyroid-related protein (PTHrP).
What does elevated PTHrP mean?
Elevations of PTHrP are the most common cause of malignancy-associated hypercalcemia. PTHrP leads to hypercalcemia by stimulating calcium resorption from bone and reabsorption in the kidneys.
Do you get hypercalcemia with lymphoma?
Hypercalcemia is uncommonly associated with lymphoma but may be seen particularly in centres where many patients with this disease are treated. Hypercalcemia readily responds to therapy and is a reversible cause of morbidity, but when associated with lymphoma it usually indicates widespread disease.
Can lymphoma cause high calcium levels?
Blood-borne cancers such as lymphoma and multiple myeloma can also cause high calcium levels.
What cancers cause high calcium in urine?
Certain cancers can cause it, especially advanced stages of the following cancers:
- multiple myeloma.
- breast.
- parathyroid gland. Close. parathyroid gland.
- lung.
- kidney.
- non-Hodgkin lymphoma.
- leukemia.
- bone metastases (cancer that has spread to the bone from other places in the body)
What cancers are associated with high calcium levels?
The types of cancers that are most commonly associated with high blood calcium are:
- myeloma – about 30 in 100 people (about 30%) have high calcium when they are first diagnosed.
- breast cancer.
- lung cancer.
- kidney cancer.
- prostate cancer.
Which malignancy is most commonly associated with hypercalcemia?
The most common cancers associated with hypercalcemia in the United States are breast, renal, and lung cancer and multiple myeloma [2]. Malignancy is usually evident clinically by the time it causes hypercalcemia, and patients with hypercalcemia of malignancy often have a poor prognosis.
What is a normal PTHrP?
Normal range . ALL . PTHrP <2.5 pmol/L .
