What is hepcidin and ferroportin?
Hepcidin-ferroportin interaction determines the flow of iron into plasma. Hepcidin concentration is in turn regulated by iron, erythropoietic activity, and inflammation. When ferroportin is located in the cell membrane it allows efflux of iron from the cells into plasma.
Do hepatocytes have ferroportin?
Ferroportin1 (FPN1, SLC40A1) is the only known membrane protein that transports iron out of cells2. It is highly expressed in cells involved in iron uptake, storage and reuse, such as duodenal epithelial cells, hepatocytes, reticuloendothelial macrophages and placental syncytiotrophoblasts3.
Is ferroportin and transferrin the same?
Ferroportin is the major iron export protein located on the cell surface of enterocytes, macrophages and hepatocytes, the main cells capable of releasing iron into plasma for transport by transferrin.
What cells have ferroportin?
Early work confirmed that ferroportin is highly expressed by cells and tissues associated with iron transport: duodenal enterocytes, liver Kupffer cells and splenic red pulp macrophages, periportal hepatocytes, and the placental syncytiotrophoblast (Figure 1).
What produces ferroportin?
Ferroportin is regulated by hepcidin, a hormone produced by the liver; hepcidin binds to Fpn and limits its iron-efflux activity, thereby reducing iron delivery to the blood plasma….
| Ferroportin | ||
|---|---|---|
| Species | Human | Mouse |
| Entrez | n/a | n/a |
| Ensembl | n/a | n/a |
| UniProt | n a | n/a |
How does hepcidin regulate ferroportin?
Hepcidin inhibits iron release at both of these sites by binding to cell-surface ferroportin and causing its internalization and subsequent degradation. Hepcidin can therefore be considered as a negative regulator of iron absorption and recycling.
How does hepcidin bind to ferroportin?
Hepcidin binds to the iron exporter ferroportin, inducing its degradation and thus preventing iron entry into plasma. We determined that hepcidin binding to ferroportin leads to the binding and activation of the protein Janus Kinase2 (Jak2), which is required for phosphorylation of ferroportin.
Which is the major storage ferroportin?
The liver is the primary storage site in the body, with the spleen and bone marrow being the other major storage sites.
Where is ferroportin produced?
Tissue distribution. Ferroportin is found on the basolateral membranes of intestinal epithelia of mammals, including: Enterocytes in the duodenum. Hepatocytes.