What is meant by chemical compatibility?
Chemical compatibility is a measure of how stable a substance is when mixed with another substance. If two substances can mix together and undergo a chemical reaction, they are considered compatible. So, incompatible is vice versa.
What is chemical incompatibility examples?
Inorganic nitrate salts or bases and organics can form highly unstable compounds which may detonate. Mixing silver nitrate and ammonia with sodium or potassium hydroxide can form explosive “fulminating silver”. Mixing silver nitrate and ethanol has resulted in serious fires.
What is incompatible mixture?
Incompatible Chemical Mixtures: These combinations may produce fire, explosion or poisonous gases so efforts must be made to ensure that such mixtures do not occur. Avoiding these reactions is the main reason for segregating stored chemicals into different parts of the laboratory or store room.
Why incompatible chemicals are stored separately?
Storing incompatible chemicals together could create a hazardous reaction such as the production of toxic gas, accelerated corrosion, or an exothermic reaction (a chemical reaction that releases heat), which could result in an explosion and/or fire.
What is chemical incompatibility pharmaceutics?
Chemical incompatibilities A change in the chemical properties of pharmaceutical dosage forms as a result of a reaction between more than two substances. Causes – Carbon dioxide is emitted as a result of chemical incompatibilities.
What happens when drugs are incompatible?
Drug incompatibilities can lead to reduced drug activity or inactivity, the formation of a new toxic or nontoxic active ingredient, increased toxicity of one or more of the involved drugs, and organoleptic changes.
What are the three types of incompatibilities?
Incompatibility is defined as a change resulting and an undesirable product is formed, which may affect the safety, efficacy, appearance and stability of the pharmaceutical product. It is of three types. It includes physical, chemical and therapeutic incompatibilities.
What is chemical incompatibility and how does it occur?
Chemical incompatibility occurs when mixing two drugs changes the potency of their active ingredients. A drug that loses more than 10% of its potency when mixed with another drug is considered incompatible with that drug.
What happens when incompatible materials are mixed?
Below are some notable situations which have occurred when incompatible materials are mixed: Acids and bases (ex: hydrochloric acid and ammonium hydroxide) generally results in generation of excessive heat, including boiling over. If the mixture boils over, it may result in serious injury.
What chemicals are incompatible with copper?
Incompatible Chemicals. Chemical. Incompatible with. Copper. hydrogen peroxide. Hydrocarbons. bromine, chlorine, peroxides. Hydrogen peroxide. combustible materials, copper, iron, most metals and their salts, any flammable liquid.
What are the possible combinations of chemicals?
It is not a comprehensive list of all possible combinations and chemicals. For details on any chemical, check the MSDS. Acetic acid with chromic acid, ethylene glycol, hydroxyl compounds, nitric acid, perchloric acid, permanganates, peroxides Acetone with concentrated sulfuric and nitric acid mixtures, hydrogen peroxide