What is substance P?
Substance P’s most well-known function is as a neurotransmitter and a modulator of pain perception by altering cellular signaling pathways. Additionally, substance P plays a role in gastrointestinal functioning, memory processing, angiogenesis, vasodilation, and cell growth and proliferation.
What does the P stand for in substance P?
Substance P (SP) is an undecapeptide that derives from alpha, beta, and gamma pre-protachykinin gene transcripts and is a neurotransmitter or neuromodulator of primary nociceptive afferents (178).
How does substance P work in pain?
Researchers found that substance P caused pain through a process known as nociception. A nociceptor is a sensory neuron or nerve cell that reacts to potentially damaging stimuli by signaling the spinal cord and brain. Nociception causes the perception of pain.
What is substance P in pharmacology?
Substance P (SP) is an undecapeptide (a peptide composed of a chain of 11 amino acid residues) member of the tachykinin neuropeptide family. It is a neuropeptide, acting as a neurotransmitter and as a neuromodulator.
Does substance P cause inflammation?
The interaction of substance P with NK-1R triggers neurogenic inflammation and directly augments inflammatory processes in the lung, gut, skin and other peripheral organs (Steinhoff et al., 2014).
What does substance P stand for?
What does the P stand for in substance P? Substance P (for “powder”), identified as a gut tachykinin in 1931 and involved in the control of multiple other autonomic functions, notably pain transmission, is the focus of intense fundamental and clinical psychiatric research as a central neurotransmitter, neuromodulator, and immunomodulator, along with sister
What role does substance P have in the body?
Aprepitant is a failed antidepressant that succeeded in clinical trials for chemotherapy-induced vomiting and nausea (CIVN) and was FDA approved for treating CIVN in 2004.
What does substance P mean?
In the field of neuroscience, substance P is a neuropeptide – a substance that functions as a neurotransmitter and as a neuromodulator. Specifically, substance P is an undecapeptide – a peptide composed of a chain of 11 amino acid residues. It belongs to the tachykinin neuropeptide family.
What is the role of substance P?
This little known plugin reveals the answer. More recently, the role of substance P has been expanded to include responding to noxious stimuli. It appears to integrate pain, anxiety, and stress. As expected with such a role, SP is found in parts of the brain that are known to be involved with emotional behavior.