What is the indication for dual antiplatelet therapy?
Indications that have been studied include coronary artery disease (CAD), atherosclerotic ischemic stroke, and atrial fibrillation. This combination has been beneficial in patients with acute coronary syndrome (ACS) with or without percutaneous coronary intervention (PCI), and in PCI patients without an acute event.
What are the indications for antiplatelet therapy?
Indications
- Acute coronary syndrome.
- Post percutaneous coronary intervention (PCI) with stenting.
- Mechanical heart valves in combination with warfarin.
- Acute ischemic stroke.
- Post percutaneous intervention of peripheral arterial disease.
- Device closure of an atrial septal defect (ASD) for at least six months.
- Stable angina.
Which antiplatelet drug is safe in renal failure?
Aspirin is the most commonly used APA in CKD patients. It inhibits COX-1 and decreases platelet thromboxane production. The antiplatelet effect of dipyridamole is mediated via phosphodiesterase inhibition (PDEI) and depends on stimulation of platelet cAMP by circulating prostacyclin (18).
Is clopidogrel removed by dialysis?
[4] However, uremic patients require long-term hemodialysis treatment, which may eliminate aspirin and clopidogrel from systemic circulation.
Who should be on DAPT?
DAPT for 12 months or more should be considered for patients at high risk of ischemic events (eg, due to prior myocardial infarction) and at low risk of bleeding.
Which of the following are indications for use of clopidogrel?
Indications
- Use during a percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS) and stable ischemic heart disease.
- Primary prevention of thromboembolism atrial fibrillation.
- Symptomatic carotid artery stenosis.
- Secondary prevention post-coronary artery bypass grafting.
When are antiplatelet drugs used?
Antiplatelet drugs may be used to: Prevent heart attack or stroke for those with PAD. Clopidogrel (Plavix, generic) may be used in place of aspirin for people who have narrowing of the coronary arteries or who have had a stent inserted.
Can you take Plavix on dialysis?
Lot of hemodialysis patients are on Clopidogrel (plavix). Their is some evidence that clopidogrel is not effective in hemodialysis as it is effective in patient without kidney problem. VerifyNow plavix is a machine that measure the ability of the blood to clot after giving plavix.
Is clopidogrel safe in CKD?
P2Y12 Receptor Antagonists The summary of product characteristics of clopidogrel recommends caution when using clopidogrel in the CKD population. The pharmacokinetics of the active metabolite of prasugrel is similar in patients with normal and in those with impaired renal function.
Why are dialysis patients at risk for bleeding?
Haemodialysis (HD) patients are at an increased risk of bleeding because of uraemic bleeding tendency and systemic anticoagulation caused by intermittent heparinization.
Which of the following is a common complication of peritoneal dialysis?
An infection of the abdominal lining (peritonitis) is a common complication of peritoneal dialysis.