Which vitamin can reduce the risk of hyperhomocysteinemia?
Folic acid alone or combined with other B-vitamins has the potential to reduce HCys concentration in patients under chronic treatment with antiepileptic drugs (8, 81).
What is the treatment of hyperhomocysteinemia?
Vitamin B(6), vitamin B(12) and folate, as co-factors in the metabolism of homosyteine, are used in the treatment of hyperhomocysteinemia. Betaine, a methyl-donor in a separate homocysteine metabolism pathway, is also used to treat hyperhomocysteinemia.
What vitamins are needed to prevent accumulation of homocysteine?
Most people who have a high homocysteine level don’t get enough folate (also called folic acid), vitamin B6, or vitamin B12 in their diet. Replacing these vitamins often helps return the homocysteine level to normal. Other possible causes of a high homocysteine level include: Low levels of thyroid hormone.
Which drugs for treatment of hyperhomocysteinemia are used?
Drugs used to treat Hyperhomocysteinemia
| Drug name | Rating | Rx/OTC |
|---|---|---|
| View information about Deplin Deplin | 10 | Rx |
| Generic name: l-methylfolate systemic Drug class: vitamins For consumers: dosage, interactions, side effects | ||
| View information about Folbee Folbee | Rate | Rx/OTC |
Does B12 lower homocysteine levels?
The most important nutrients that help lower homocysteine levels are folate, the vitamins B12, B6 and B2, zinc and trimethylglycine (TMG).
What is the treatment of homocystinuria?
Treatment. There is no cure for homocystinuria. About half of people with the disease respond to vitamin B6 (also known as pyridoxine). Those who do respond will need to take vitamin B6, B9 (folate), and B12 supplements for the rest of their lives.
Which foods reduce homocysteine?
Studies show foods containing folic acid may lower homocysteine. Try beans, leafy green vegetables, citrus fruits, beets, and wheat germ. A controlled trial showed that eating a diet high in fruits and vegetables containing folic acid, beta-carotene and vitamin C effectively lowered homocysteine levels.
What is homocysteine supplement used for?
Homocysteine is an amino acid. Vitamins B12, B6 and folate break down homocysteine to create other chemicals your body needs. High homocysteine levels may mean you have a vitamin deficiency. Without treatment, elevated homocysteine increases your risks for dementia, heart disease and stroke.
How are folic acid vitamin B12 and homocysteine related?
Normal Absorption of Vitamin B In the second reaction, homocysteine is converted to methionine by using vitamin B12 and folic acid as cofactors. In this reaction, a deficiency of vitamin B12 or folic acid may lead to increased homocysteine levels.
Does vitamin D lower homocysteine?
In conclusion, vitamin D3 intervention with a treatment dose of 50 000 IU per week for at least 2 months can help decrease BMI and homocysteine levels, which in turn will help prevent or minimize the risk of CVD among overweight women of reproductive age.
Does vitamin C lower homocysteine?
The bottom line for the consumer who wishes to lower his/her plasma levels of homocysteine is that a dose of Vitamin C in the range of 500 mg per day or greater may interfere with Folic acid’s ability to accomplish this.
What are the nutritional etiologies of hyperhomocysteinemia?
Nutritional etiologies of hyperhomocysteinemia. Normal homocysteine metabolism is dependent upon adequate stores of three dietary vitamins: folic acid, vitamin B12 (cobalamin), and vitamin B6 (pyridoxal phosphate).
What is the role of vitamin therapy in the treatment of hyperhomocysteinemia?
If effective, the simplicity, availability, and presumably favorable side effect profile of hyperhomocysteinemia treatment with combined folic acid and oral B6- and B12-vitamin supplementation (collectively referred to in this text as vitamin therapy) makes this an attractive addition to standard medical therapy for cardiovascular diseases.
Does homocysteine lowering therapy prevent vascular events in hyperhomocysteinemia?
Sufficiently powered studies are needed to test the effect of homocysteine lowering therapy for prevention of vascular events in patients with mildly or moderately reduced creatinine clearance. Other medical etiologies of hyperhomocysteinemia Hypothyroidism and estrogen deficiency states are associated with hyperhomocysteinemia (8).
Which factors increase the risk of atherosclerosis in hyperhomocysteinemia?
Robinson K, Gupta A, Dennis V, Arheart K, Chaudhary D, et al. Hyperhomocysteinemia confers an independent increased risk of atherosclerosis in end-stage renal disease and is closely linked to plasma folate and pyridoxine concentrations. Circulation. 1996;94:2743–8.