Can amiodarone cause hyperthyroidism?
However, amiodarone is associated with a number of side effects, including thyroid dysfunction (both hypo- and hyperthyroidism), which is due to amiodarone’s high iodine content and its direct toxic effect on the thyroid.
How is amiodarone-induced hyperthyroidism treated?
Overall, mild AIT resolves spontaneously in approximately 20% of cases (20). Type 1 AIT is treated with a thionamide because it is caused by increased hormonal synthesis (10). Higher than average doses are often required (eg, propylthiouracil 450 mg to 600 mg daily, or methimazole 30 mg to 40 mg daily).
Can amiodarone cause thyroid storm?
Amiodarone-induced thyrotoxicosis was the most common cause of thyroid storm (33%), followed by Graves’ disease (26%). Autoimmune thyroiditis, toxic multinodular goiter, and toxic solitary thyroid adenoma were much less frequent causes (10%, 9%, and 6% respectively).
Can amiodarone cause Graves disease?
There are two distinct forms of amiodarone-induced thyrotoxicosis (AIT): type 1 AIT when the high iodine content of amiodarone precipitates an underlying thyroid disease (Graves’ disease or toxic nodules) and causes hyperthyroidism and type 2 AIT, in which a destructive inflammation caused by amiodarone causes a …
How long does amiodarone affect thyroid?
If amiodarone is stopped in patients with type II AIT the majority will become and remain euthyroid within 3–5 months of amiodarone withdrawal [Bartalena et al. 1996; Martino et al. 1987a]. Some may eventually become hypothyroid either spontaneously or after re-exposure to iodine [Bogazzi et al.
How long does it take amiodarone to get out of your system?
Amiodarone has a very long half-life (this is the time it takes for 50% of a dose of amiodarone to be eliminated by the body) of 15 to 142 days. It also has an active metabolite, desethylamiodarone that has a half-life of 75 days.
How quickly can amiodarone affect thyroid?
After 1–4 months of amiodarone therapy, serum T4 levels increase by an average of 40% above pretreatment levels. It is important to note that the increase in T4 levels is an expected finding and in itself does not constitute evidence of hyperthyroidism.
How long does amiodarone stay in your system?
What is the thyroid storm?
Thyroid storm is a very rare, but life-threatening condition of the thyroid gland that develops in cases of untreated thyrotoxicosis (hyperthyroidism, or overactive thyroid). The thyroid gland is located in the neck, just above where your collarbones meet in the middle.
Do amiodarone side effects go away?
Some side effects of amiodarone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
