What is the other name of nikethamide?
Nikethamide is a stimulant which mainly affects the respiratory cycle. Widely known by its former trade name of Coramine, it was used in the mid-twentieth century as a medical countermeasure against tranquilizer overdoses, before the advent of endotracheal intubation and positive-pressure lung expansion.
What is the mechanism of action of nikethamide?
Nikethamide increases the development of tension of a muscle stimulated indirectly at low frequencies (fig. 2A and 2B) and produces a depression of muscular contraction when the stimuli are of higher frequencies (fig. 1 and 2C). Nikethamide depresses the first stage of neuromuscular transmission (fig.
Is Nikethamide CNS stimulant?
Early drugs of this type such as nikethamide were used as respiratory stimulants, but at doses effective for stimulating respiration they had an unacceptably high incidence of CNS toxicity such as headache, agitation, muscle spasms or convulsions.
What is use of nikethamide?
Nikethamide has actions similar to doxapram hydrochloride and was formerly given intravenously, intramuscularly, subcutaneously, or orally for the treatment of overdose due to nervous system depressants, such as morphine, barbiturates and anticholinesterases [1–4] and in patients with chronic respiratory acidosis [5].
What is another name for aminophylline?
What brand names are available for aminophylline? Norphyl, Phyllocontin, Truphylline.
What is the indication of aminophylline?
Aminophylline Injection is indicated for relief of bronchospasm associated with asthma and in chronic obstructive pulmonary disease.
What is Nikethamide used for?
What drugs are Analeptic?
Among them are alkaloids (nicotine), methylxanthines (caffeine and theophylline), cocaine, amphetamines, and benzhydrylsulfinylacetamides (modafinil and armodafinil).
What is a respiratory stimulant?
Respiratory stimulants are medications used to stimulate respiration post anesthesia or to treat respiratory conditions such as chronic obstructive pulmonary disease (COPD), respiratory depression/failure, and neonatal apnea. Respiratory stimulants improve the respiratory drive and oxygen inflow as a result.
What are the side effects of nikethamide?
In addition to generalized restlessness, the adverse effects of nikethamide are itching, flushing, sweating, coughing, nausea, vomiting, muscle twitching, especially of the face, and convulsions (1–3). These are actually toxic effects, the margin between the clinically effective dose and the toxic dose being very narrow.
What is nikethamide annotated for?
It is scheduled to be annotated soon. Nikethamide is a nicotinic acid derivative indicated as a respiratory stimulant. with evidence-based and structured datasets. Build, train, & validate predictive machine-learning models with structured datasets.
What does nicethamid taste like?
It derives from a nicotinamide. Nicethamid appears as clear light yellow viscous liquid or crystalline solid. Slightly bitter taste followed by a faint sensation of the warmth. (NTP, 1992) Computed by Lexichem TK 2.7.0 (PubChem release 2021.05.07)
What is nikethamide and why did Serena Williams test positive?
The American tested positive for banned stimulant nikethamide on April 24, but claimed it had entered her system through Coramine Glucose tablets and that, as there was no intention to improve her performance with the substance, she should have been clear.
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