Does dapsone cause megaloblastic anemia?
Dapsone may induce a dose-related hemolytic anemia, which is more likely with doses greater than 200 mg/day or in patients with glucose-6-phosphate dehydrogenase (G-6-PD) deficiency. Leukopenia, megaloblastic pancytopenia, and hemolysis have been reported.
What vitamin helps with megaloblastic anemia?
In the case of megaloblastic anemia caused by vitamin B12 deficiency, you may need monthly injections of vitamin B12. You may also be given oral supplements. Adding more foods with vitamin B12 to your diet can help.
Which drugs will you prescribe for the patient with megaloblastic anemia?
Mecobalamin. MeCbl is now prescribed for the treatment of vitamin B12 deficiency and is slowly replacing the traditional B12 formulations like cyanocobalamin and hydroxocobalamin.
Which antiepileptic drug causes megaloblastic anemia?
Diphenylhydantoin, primidone (Mysoline), and barbiturates either singly or in combination have been shown capable of inducing megaloblastic anemia.
Does dapsone cause anemia?
Dapsone has long been known to cause hemolytic anemia, especially in people with G6PD deficiency; it causes a drop in hemoglobin levels up to 3 g/dL in up to 16% of the patients who receive a standard dose.
What is the commonest side effect of dapsone?
Nausea, vomiting, loss of appetite, dizziness, or blurred vision may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.
What vitamins should I take for anemia?
Most adults need these daily dietary amounts of the following vitamins: Vitamin B-12 — 2.4 micrograms (mcg) Folate or folic acid — 400 mcg….Foods rich in vitamin B-12 include:
- Beef, liver, chicken and fish.
- Eggs.
- Fortified foods, such as breakfast cereals.
- Milk, cheese and yogurt.
What is the danger of treating megaloblastic anemia empirically with folic acid?
Folate therapy should not be instituted in a patient with megaloblastic anemia if cobalamin deficiency has not been definitively ruled out. The danger is that folic acid will improve the anemia but not the neurological complications of cobalamin deficiency, and the neurological disorder will worsen.
What is megaloblastic anaemia?
Megaloblastic anemia is a type of anemia characterized by very large red blood cells. In addition to the cells being large, the inner contents of each cell are not completely developed. This malformation causes the bone marrow to produce fewer cells, and sometimes the cells die earlier than the 120-day life expectancy.
What are the causes of megaloblastic anemia?
The most common causes of megaloblastic anemia are deficiency of either cobalamin (vitamin B12) or folate (vitamin B9). These two vitamins serve as building blocks and are essential for the production of healthy cells such as the precursors to red blood cells.
How is megaloblastic anemia treated?
Megaloblastic anemia secondary to folate deficiency is generally treated with oral folate, as it is most often caused by dietary deficiency rather than malabsorption. For supplementation and treatment, it is available as either of the following: The synthetic form, known as folic acid or pteroylglutamic acid.