What causes Potter syndrome?
Causes. The most common underlying cause of Potter syndrome is absence, underdevelopment or malformation of the kidneys. Absence of both kidneys (bilateral renal agenesis) is the most common condition associated with Potter syndrome.
Why does renal agenesis cause oligohydramnios?
The kidneys develop between the 5th and 12th week of fetal life, and by the 13th week they are normally producing urine. When the embryonic kidney cells fail to develop, the result is called renal agenesis. It is often detected on fetal ultrasound because there will be a lack of amniotic fluid (called oligohydramnios).
What causes platelet dysfunction?
Platelet dysfunction may stem from an intrinsic platelet defect or from an extrinsic factor that alters the function of normal platelets. Dysfunction may be hereditary or acquired. Hereditary disorders of platelet function consist of von Willebrand disease. Bleeding tendency is usually mild.
Is Potter’s syndrome fatal?
Potter syndrome is a fatal congenital disorder characterized by the changes in physical appearances of neonate due to oligohydramnios caused by renal agenesis and impairment.
What is Potter face?
Potter facies is described as having a flattened nose, recessed chin, prominent epicanthial folds, and low set of abnormal ears. The degree of pulmonary hypoplasia depends on the degree and duration of oligohydramnios, as well as the stage of lung development at which oligohydramnios occurs.
What gene causes renal agenesis?
Renal agenesis results from a developmental failure of the ureteric bud and the metanephric mesenchyme. Unilateral renal agenesis can be caused by mutations in many genes , such as RET (10q11. 2), BMP4 (14q22-q23), FRAS1 (4q21. 21), FREM1 (9p22.
What birth defects are associated with oligohydramnios?
Oligohydramnios can cause the following injuries and complications:
- Increased risk of miscarriage or stillbirth.
- Compression of fetal organs that can lead to birth asphyxia or hypoxic-ischemic encephalopathy (HIE)
- Premature birth.
- Intrauterine growth restriction (IUGR)
- Cord prolapse.
- Cerebral palsy.
- Preterm birth.
What drugs cause low platelets?
Platelets are cells in the blood that help the blood clot. A low platelet count makes bleeding more likely….Other medicines that cause drug-induced thrombocytopenia include:
- Furosemide.
- Gold, used to treat arthritis.
- Nonsteroidal anti-inflammatory drugs (NSAIDs)
- Penicillin.
- Quinidine.
- Quinine.
- Ranitidine.
- Sulfonamides.
What is the Bernard Soulier syndrome?
Bernard-Soulier syndrome is a bleeding disorder associated with abnormal platelets, which are blood cells involved in blood clotting. In affected individuals, platelets are unusually large and fewer in number than usual (a combination known as macrothrombocytopenia).