What is Cardizem CD used for?
Cardizem CD capsules are used to prevent angina or to treat hypertension (high blood pressure). Angina is a pain or uncomfortable sensation in the chest, often spreading to the arms or neck and sometimes to the shoulders and back. The pain of angina is due to a shortage of oxygen to the heart.
How does diltiazem work AV node?
Diltiazem is a potent vasodilator, increasing blood flow and variably decreasing the heart rate via strong depression of A-V node conduction. It binds to the alpha-1 subunit of L-type calcium channels in a fashion somewhat similar to verapamil, another nondihydropyridine (non-DHP) calcium channel blocker.
What is a Class III drug?
Schedule III Schedule III drugs, substances, or chemicals are defined as drugs with a moderate to low potential for physical and psychological dependence. Schedule III drugs abuse potential is less than Schedule I and Schedule II drugs but more than Schedule IV.
What drug class is Cardizem CD?
Cardizem CD belongs to a class of drugs called Antidysrhythmics, IV; Calcium Channel Blockers; Calcium Channel Blockers, Non-dihydropyridine.
What is the generic name for Cardizem CD?
Teva’s generic of Cardizem® CD Capsules: Cartia XT® (Diltiazem HCl Extended-Release Capsules, USP)
Is Cardizem CD Extended Release?
Cardizem CD is formulated as a once-a-day extended-release capsule containing 120 mg, 180 mg, 240 mg, 300 mg, or 360 mg diltiazem hydrochloride.
Is Cardizem CD the same as dilacor XR?
Dilacor XR was equivalent to Cardizem CD with respect to AUC((0–infty infinity)) and C(max). Equivalent minimum and average steady-state plasma diltiazem concentrations were noted after multiple-dose administration.
Why is Cardizem contraindicated in WPW?
Diltiazem should be avoided in the presence of pre-excited AF with RVR, that is, AF in the presence of accessory pathway, i.e. Wolff Parkinson White (WPW) syndrome, as AVN blockage can lead to increased conduction through the accessory pathway, leading to life-threatening rapid ventricular rates.
Do calcium channel blockers affect the AV node?
In the heart, nondihydropyridine calcium channel blockers, such as diltiazem (Cardizem), slow excitability of the SA node, decrease conduction through the AV node, and reduce myocardial contractility.