What is the role of ceruloplasmin in iron production?
Ceruloplasmin, a ferroxidase, is important also for iron transport. By oxidizing ferrous iron to the ferric form, ceruloplasmin promotes iron loading onto transferrin, which binds only the ferric form of the metal.
What can cause low ceruloplasmin?
Low levels of ceruloplasmin can be caused by several different factors:
- Long-term liver disease.
- Improper nutrition (malnutrition)
- Inability to absorb nutrients from food (malabsorption)
- Disorders that cause kidney damage (nephrotic syndrome)
- Disorder that makes your body unable to distribute copper (Menkes syndrome)
What causes elevated ceruloplasmin?
Your ceruloplasmin level can be higher than normal because of pregnancy, estrogen therapy, and birth control pills. Diseases such as leukemia, Hodgkin lymphoma, primary biliary cirrhosis, and rheumatoid arthritis can also cause a higher ceruloplasmin level.
Is ceruloplasmin involved in iron homeostasis?
Ceruloplasmin (Cp) is a ferroxidase that also plays a role in iron efflux from cells. It can thus help to regulate cellular iron homeostasis.
How do you increase ceruloplasmin?
Increasing Ceruloplasmin Check your copper levels. Low levels of ceruloplasmin are sometimes linked to low levels of copper. If your copper is low, you may need to increase it. In addition, if you’re taking zinc supplements, you may want to stop or decrease the dosage, since zinc can compete with copper for absorption.
Is ceruloplasmin low in copper deficiency?
When urine and serum concentrations of both copper and ceruloplasmin are low, then the patient is simply suffering from a copper deficiency. Anything interfering with the body’s ability to metabolize copper may also affect the serum ceruloplasmin levels.
Does low ceruloplasmin always mean Wilson’s disease?
Blood tests Ceruloplasmin, a protein that carries copper in the bloodstream. People with Wilson’s disease often have low ceruloplasmin levels, but not always. Copper. People with Wilson disease may have lower than normal blood copper levels.
What happens when ceruloplasmin is high?
If your ceruloplasmin levels were higher than normal, it may be a sign of: A serious infection. Heart disease. Rheumatoid arthritis.
What happens if ceruloplasmin is low?
Ceruloplasmin is a protein that binds to copper and helps it move throughout your body. If you have low ceruloplasmin, it can point to conditions like copper deficiency, Wilson’s disease, rheumatoid arthritis or Menkes disease.