What is the ring-opening of epoxide?
Epoxide Ring-Opening by HX Epoxides can also be opened by anhydrous acids (HX) to form a trans halohydrin. When both the epoxide carbons are either primary or secondary the halogen anion will attack the less substituted carbon through an SN2 like reaction.
What is the alternative name for epoxides?
| IUPAC | Oxirane | Oxolane |
| Common | ethylene oxide | tetrahydrofuran |
Is epoxidation of alkenes regioselective?
Epoxidation of alkenes by molecular oxygen is effected in high yields by catalysis of RuCl2(biox)2 using isobutyralde- hyde as the co-reductant: the reaction is stereospecific and regioselective.
What is an example of a ring opening polymerization?
Anionic ring-opening polymerizations (AROP) involve nucleophilic reagents as initiators. Monomers with a three-member ring structure – such as epoxides, aziridines, and episulfides – undergo anionic ROP. A typical example of anionic ROP is that of ε-caprolactone, initiated by an alkoxide.
What is the structure of epoxide?
epoxide, cyclic ether with a three-membered ring. The basic structure of an epoxide contains an oxygen atom attached to two adjacent carbon atoms of a hydrocarbon. The strain of the three-membered ring makes an epoxide much more reactive than a typical acyclic ether.
What is epoxidation of alkenes?
Alkenes are capable of reacting with oxygen in the presence of elemental silver to form a series of cyclic ethers called epoxides. Epoxides are three‐atom cyclic systems in which one of the atoms is oxygen. The simplest epoxide is epoxyethane (ethylene oxide).
Which monomer is used for ring-opening polymerization?
Ring-opening polymerization (ROP) is another type of polymerization in which monomers such as amides, acetals esters, cyclic ethers, and siloxanes are used [1].
What is the epoxide ring-opening protocol used for?
Importantly, this epoxide ring-opening protocol can be used for the introduction of amines in natural products during late-stage transformations.
Is there an acetic acid-mediated ring-opening reaction of epoxides with amines?
We herein report a metal- and solvent-free acetic acid-mediated ring-opening reaction of epoxides with amines. This process provides β-amino alcohols in high yields with excellent regioselectivity.
What is regioselectivity and why is it important?
Regioselectivity has now become an important focus for the ring-opening reaction of unsymmetrical epoxides, where obtaining one regioisomer exclusively is extremely difficult to achieve.