What are Radioprotectants?
Type A2 radioprotectants: free radical scavengers Use of free radical scavengers at this stage would reduce the number of free radicals that damage DNA or organelles. All cells contain a certain level of endogenous scavengers, the expression of which can be induced under stressful conditions.
What is a Radiomitigator?
Radiation mitigators aim to interrupt these cascades or intervene to prevent the perpetuation of damage and thus reduce the expression of toxicity.
How do radioprotective drugs work?
Radioprotective compounds may suppress free radical formation, remove free radicals, induce natural radioprotector production (such as superoxide dismutase, glutathione peroxidase, and catalase), enhance DNA repair, reduce the post-radiation inflammatory response, or even delay cellular division allowing more time for …
Which drug is considered a radiosensitizer?
These drugs include nitroimidazole, misonidazole, etanidazole, nimorazole, and efaproxaril. 2. Hypoxic cytotoxins presumably play their role by selectively killing hypoxic cells, which are generally more resistant to radiation.
What chemotherapy drugs are radiosensitizers?
Radiation sensitizers include primarily traditional chemotherapy agents (i.e., gemcitabine, interferon-α, 13-cis-retinoic acid, doxorubicin, docetaxel, carboplatin, cisplatin, dactinomycin, methotrexate, 5-FU, bleomycin, and hydroxyurea).
Is chemotherapy a radiosensitizer?
Chemotherapeutic drugs administered at subtoxic doses act by means of a radiosensitization mechanism. Platinum-derived drugs have been historically used as radiosensitizers, without cumulative unacceptable toxicity.
What do you mean by radiosensitizer?
Listen to pronunciation. (RAY-dee-oh-SEN-sih-TY-zer) Any substance that makes tumor cells easier to kill with radiation therapy. Some radiosensitizers are being studied in the treatment of cancer.
Which of the following is an example of radiosensitizer?
Examples of radiosensitizers currently in use are cisplatin and gemcitabine, although many molecularly targeted agents are currently under investigation as potential radiosensitizers. Radioprotectors are agents that protect cells (organs, organisms) from the damaging effects of ionizing radiation.
