How is hepatic artery infusion done?
Hepatic arterial infusion delivers chemotherapy through a pump that’s implanted in the abdominal wall. “We then use a catheter to deliver high doses of chemotherapy through the hepatic artery, which directly feeds metastatic tumors in the liver,” said Peter Allen, MD, a Duke surgical oncologist.
What is an intra-arterial procedure?
INTRODUCTION. Intra-arterial catheters (also called arterial cannulas or A-lines) are often inserted for invasive blood pressure (BP) monitoring and intravascular access for blood sampling in high-risk surgical and critically ill patients.
What is hepatic injection?
Hepatic 5mg Injection is a combination of amino acids that are used in the treatment of liver disease. It protects the liver from harmful chemical substances and improves the functioning of the liver.
How successful is hepatic artery infusion?
In a 2005 report, 41% of patients who received HAI with chemotherapy were alive 10 years after resection. In addition to CLMs, HAI can be performed as an adjunct to surgery for chalangiocarcinoma within the liver, where studies suggest outcomes similar to those for CLMs.
How long do you keep a HAI pump in for?
The HAI pump is usually in place for six months to one year, often longer than originally necessary to ensure we won’t need it again. Placement of the pump requires surgical procedure. It sits within your skin, and one end of it goes deep within your abdomen.
How is intra-arterial administered?
What is intra-arterial chemotherapy? Traditional chemotherapy is administered through a catheter into a peripheral vein. This means the chemotherapy drug has to pass via the heart and lungs before being delivered to the cancer, and therefore the drug is diluted by the time it reaches the target.
What is intra-arterial monitoring?
Invasive blood pressure monitoring: Invasive (intra-arterial) blood pressure (IBP) monitoring is a commonly used technique in the Intensive Care Unit (ICU) and is also often used in the operating theatre. This technique involves direct measurement of arterial pressure by inserting a cannula needle in a suitable artery.
What is intra-arterial thrombolysis?
Intra-arterial thrombolysis involves the administration of agents directly into an artery to break down thrombus. While many agents are available, those used for intra-arterial thrombolysis are classified as plasminogen activators.
What medications can be given through an arterial line?
Among the anesthetic drugs that have been injected intraarterially without adverse effects are fentanyl, midazolam, succinylcholine, pancuronium, and atropine (Table 1).
How do you extract an injection?
Filling the Syringe With Medicine
- Hold the syringe in your hand like a pencil, with the needle pointed up.
- With the cap still on, pull back the plunger to the line on your syringe for your dose.
- Insert the needle into the rubber top.
- Push the air into the vial.
- Turn the vial upside down and hold it up in the air.
What are the benefits of intra-arterial (IA) Drug Administration?
The benefits of IA administration are maximized with drugs that have a high rate of biotransformation, metabolism, and excretion during the first pass (i.e., total body drug clearance; CLtb). BCNU, cisplatin, etoposide, methotrexate, and carboplatin are only some of the drugs that have been used intra-arterially to treat PBT and MBT [ 3,8 ].
What is the difference between intraarterial and extravasation?
Intraarterial Drug Administration. Intra-arterial injection is extremely painful, whereas extravasation in the subcutaneous tissue may remain asymptomatic, unless the sclerosant solution had been mixed with normal saline, or a high concentration of sclerosant had been used.
What is intra-arterial chemotherapy?
Intra-arterial (IA) chemotherapy is a form of regional delivery to brain tumors, designed to enhance the intra-tumoral concentrations of a given drug, in comparison to the intravenous route.
Is direct intra-arterial infusion of plasminogen activator safe and effective?
Hence, both recanalization and hemorrhage appear to be dependent on the use of both plasminogen activator and the anticoagulant in those studies. In summary, two controlled trials of direct intra-arterial infusion plasminogen activators indicate the feasibility and relative safety of this approach.